Tweak

Tweak
Author: Nic Sheff
Pages: 368
ISBN: 9781471109737
Available:
Release: 2012-12-11
Editor: Simon and Schuster
Language: en

Explanation of the Book:

THE NEW YORK TIMES BESTSELLER NOW A MAJOR FILM, STARRING STEVE CARELL AND BAFTA AND GOLDEN GLOBE NOMINATED TIMOTHEE CHALAMET ‘It was like being in a car with the gas pedal slammed down to the floor and nothing to do but hold on and pretend to have some semblance of control. But control was something I'd lost a long time ago.’ Nic Sheff was drunk for the first time at age 11. In the years that followed, he would regularly smoke pot, do cocaine and ecstasy, and develop addictions to crystal meth and heroin. Even so, he felt like he would always be able to quit and put his life together whenever he needed to. It took a violent relapse one summer to convince him otherwise. In a voice that is raw and honest, Nic spares no detail in telling us the compelling true story of his relapse and the road to recovery. He paints an extraordinary picture for us of a person at odds with his past, with his family, with his substances, and with himself. Tweak is a raw, harrowing, and ultimately hopeful tale of the road from relapse to recovery and complements his father’s parallel memoir, Beautiful Boy. Praise for Nic Sheff:- ‘Difficult to read and impossible to put down.’Chicago Tribune 'Nic Sheff's wrenching tale is told with electrifying honesty and insight.' Armistead Maupin

Tweak to Transform

Tweak to Transform
Author: Mike Hughes
Pages: 264
ISBN: 9781855391406
Available:
Release: 2002-08-01
Editor: A&C Black
Language: en

Explanation of the Book:

Improving teaching is the key to genuine and sustainable school improvement. Improvement involves persuading teachers to change and develop their practice but, as anyone who has ever tried will testify, this is far from easy. The focus of Tweak to Transform is what head teachers and school leaders can do to manage the change process and improve the quality of teaching in a school. Essentially, Tweak to Transform is a practical handbook that seeks to address three questions. What do we know about change? What do we know about learning? What do we know about leading and managing the improvement process? While there is no single successful recipe for improving teaching in a school, this book attempts to establish some key principles. The result is a collection of thoughts, activities strategies and models that have been developed and successfully implemented in a wide range of schools. >

Tweak

Tweak
Author: Nic Sheff
Pages: 337
ISBN: 9781416972198
Available:
Release: 2009-01-06
Editor: Simon and Schuster
Language: en

Explanation of the Book:

Sheff relates his personal struggle with drugs and alcohol in this poignant and often disturbing memoir. Paul Michael Garcia is the perfect choice for narrator; his stern and entirely believable voice captures the desolation in Sheff's tale. His reading is wonderfully underplayed, and necessarily so. Garcia becomes Sheff, offering a gritty and raw performance that demonstrates just how dire the circumstances surrounding Sheff's existence really were.

Tweak It

Tweak It
Author: Cali Williams Yost
Pages: 272
ISBN: 9781455517862
Available:
Release: 2013-01-08
Editor: Center Street
Language: en

Explanation of the Book:

As the demands of work grow more intense, personal life can get shoved to the side. But resolving the job-versus-life conflict doesn't require the kind of big, disruptive, scary transformation that so many time-management "experts" recommend. In TWEAK IT, Cali Williams Yost proves that a comfortable work+life fit can be achieved through making small, consistent, everyday changes--tweaks--that, cumulatively, will optimize job performance and well-being. This engaging, practical book, filled with case studies of people who've tweaked their way to professional success and personal satisfaction, guides readers through an easy-to-implement program that can be tailored to suit any individual's life, both on off the job.

TweAK

TweAK
Author: James Bryron Love
Pages: 35
ISBN:
Available:
Release: 2013-08-01
Editor: Spangaloo
Language: en

Explanation of the Book:

In the multi-verse there exists those that would tamper with the realities of your world. They have the technology to change everything and anything. They even get to decide if you were ever born. They are a nasty sort with out a speck of compassion. There are others bent on balance with the same technology so who is really running the universe?

Regulation of Tissue Responses The TWEAK Fn14 Pathway and other TNF TNFR Superfamily Members that Activate Noncanonical NFkB Signaling

Regulation of Tissue Responses  The TWEAK Fn14 Pathway and other TNF  TNFR Superfamily Members that Activate Noncanonical NFkB Signaling
Author: Linda C. Burkly,Timothy S. Zheng,John Silke
Pages: 329
ISBN: 9782889197002
Available:
Release: 2016-01-21
Editor: Frontiers Media SA
Language: en

Explanation of the Book:

The immune system mediates tissue responses under both physiological and pathological conditions, impacting the inflammatory, fibrogenic and regenerative components. In addition to various leukocyte subsets, it is now recognized that epithelial, endothelial and other non-hematopoietic tissue cell types actively contribute to the interplay shaping tissue responses. Further understanding the molecular pathways and mechanisms mediating these tissue responses is of great interest. In the past decade, TNF-like weak inducer of apoptosis (TWEAK) and its receptor, FGF-inducible molecule-14 (Fn14), members of the TNF/TNFR superfamily, have emerged as a prominent molecular axis regulating tissue responses. Generally leukocyte-derived, TWEAK signals through Fn14 which is highly induced in injured and diseased tissues on the surface of parenchymal, stromal and progenitor cells, thereby orchestrating a host of tissue-shaping responses, including inflammation, angiogenesis, cell proliferation or death, and the regulation of progenitor cells. Compelling preclinical results indicate that whereas transient TWEAK/Fn14 activation promotes productive tissue responses after acute injury, excessive or persistent TWEAK/Fn14 activation drives pathological tissue responses, leading to progressive damage and degeneration in target organs of injury, autoimmune and inflammatory diseases and cancer. Given that the highly inducible pattern of Fn14 expression is well conserved between mouse and man, the role of TWEAK/Fn14 in human disease is an area of intense investigation. Recent findings have also begun to shed light on how the TWEAK/Fn14 pathway fits into the immune network, interplaying with other well-established pathways, including TNFa, IL-17, IL-13 and TGFb, in regulating tissue responses. The noncanonical nuclear factor kB (NF?B) pathway plays a role in immunity and disease pathologies and appears to be activated by only a subset of TNF/ TNFR superfamily members. Of the various signaling pathways downstream of TWEAK/Fn14, particular attention has been placed on the noncanonical NF?B pathway given that given that TWEAK induces acute activation of canonical NF?B but prolonged activation of noncanonical pathway. Thus dovetailing of the TWEAK/Fn14 axis with noncanonical NF?B pathway activation may be a key mechanism underlying tissue responses. Also of great interest is a deeper understanding of where, when and how tissue responses are regulated by other TNF/ TNFR superfamily members that can signal through noncanonical NF?B. This Research Topic issue will cover: 1. TWEAK/Fn14 pathway biology, role in tissue responses, injury, and disease pathogenesis 2. Role of noncanonical NFkB signaling cascade in tissue responses 3. Translational studies of relevance of TWEAK/Fn14 and noncanonical NFkB in human disease 4. Other TNF superfamily members’ signaling through noncanonical NFkB in the regulation of tissue responses 5. Reviews and Perspectives on the above

Tweak it Second Ed

Tweak it  Second Ed
Author: Edward Caplan
Pages: 329
ISBN: 9781300685708
Available:
Release: 2021
Editor: Lulu.com
Language: en

Explanation of the Book:

Tweak It and Freak It

Tweak It and Freak It
Author: Paul McFedries
Pages: 480
ISBN: 0768686717
Available:
Release: 2009-03-27
Editor: Pearson Education
Language: en

Explanation of the Book:

Tweak It and Freak It A Killer Guide to Making Windows Run Your Way Hundreds of millions of people use Windows every day, and it’s a safe bet that some of them would not describe themselves as happy campers. Regardless of skill level, most people have something they dislike about Windows, and they often have a whole laundry list of Windows gripes. “Why can’t Windows do this rather than that?” “Why does Windows do X instead of Y?” “Wouldn’t it be great if Windows could do Z?” Most people think Windows is set in stone, but it isn’t! Strip off that veneer and a whole world comes into view, one that’s hackable, moddable, tweakable, customizable, and personalizable. This book shows you the tools and technologies that anyone can use to hack almost every aspect of Windows, from startup to shutdown, from the interface to the Internet, from security to scripting. • Speed up your tired PC with a fistful of easy-to-do, but oh so powerful tweaks! • Tired of looking at the same old Windows day in and day out? So are we! That’s why we show you how to give Windows a makeover! • Want to be more productive at work or home? This book is full of productivity tweaks that not only make Windows more fun to use, but also save you tons of time. • Create custom backup routines that safeguard your precious data. • Tighten the security of your PC and your network to stop would-be thieves in their tracks. • Dual-boot Windows XP and Vista on the same machine, or dare we say it, run MacOS on your PC! We won’t tell. Paul McFedries is a passionate computer tinkerer and Windows expert. He is the author of more than 60 computer books that have sold more than 3 million copies worldwide. His recent titles include the Sams Publishing books Windows Vista Unleashed, Second Edition, and Windows Home Server Unleashed, and the Que Publishing books Build It. Fix It. Own It. : Networking with Windows Vista, Formulas and Functions with Microsoft Excel 2007, Tricks of the Microsoft Office 2007 Gurus, and Microsoft Access 2007 Forms, Reports, and Queries. Paul is also the proprietor of Word Spy (www.wordspy.com), a website devoted to tracking new words and phrases as they enter the English language. CATEGORY: Windows Operating System COVERS: Windows Vista and XP USER LEVEL: Beginning-Intermediate

Glycolysis at 75 Is it Time to Tweak the First Elucidated Metabolic Pathway in History

Glycolysis at 75  Is it Time to Tweak the First Elucidated Metabolic Pathway in History
Author: Avital Schurr,Evelyne Gozal
Pages: 329
ISBN: 9782889195862
Available:
Release: 2015-07-08
Editor: Frontiers Media SA
Language: en

Explanation of the Book:

Glycolysis, the pathway of enzymatic reactions responsible for the breakdown of glucose into two trioses and further into pyruvate or lactate, was elucidated in 1940. For more than seven decades, it has been taught precisely the way its sequence was proposed by Embden, Meyerhof and Parnas. Accordingly, two outcomes of this pathway were proposed, an aerobic glycolysis, with pyruvate as its final product, and an anaerobic glycolysis, identical to the aerobic one, except for an additional reaction, where pyruvate is reduced to lactate. Several studies in the 1980s have shown that both muscle and brain tissues can oxidize and utilize lactate as an energy substrate, challenging this monocarboxylate’s reputation as a useless end-product of anaerobic glycolysis. These findings were met with great skepticism about the idea that lactate could be playing a role in bioenergetics. In the past quarter of a century monocarboxylate transporters (MCTs) were identified and localized in both cellular and mitochondrial membranes. A lactate receptor has been identified. Direct and indirect evidence now indicate that the enzyme lactate dehydrogenase (LDH) resides not only in the cytosol, as part of the glycolytic pathway machinery, but also in the mitochondrial outer membrane. The mitochondrial form of the enzyme oxidizes lactate to pyruvate and concomitantly produces the reducing agent NADH. These findings have shed light on a major drawback of the originally proposed aerobic version of the glycolytic pathway i.e., its inability to regenerate NAD+, as opposed to anaerobic glycolysis that features the cyclical ability of regenerating NAD+ upon pyruvate reduction to lactate by the cytosolic form of LDH. The malate-aspartate shuttle (MAS), a major redox shuttle in the brain, was proposed as an alternative pathway for NAD+ generation for aerobic glycolysis. Nonetheless, would MAS really be necessary for that function if glycolysis always proceeds to the end-products, lactate and NAD+? An additional dilemma the originally proposed aerobic glycolysis presents has to do with the glycolytic pathway of erythrocytes, which despite its highly aerobic environment, always produces lactate as its end-product. It is time to reexamine the original, dogmatic separation of glycolysis into two distinct pathways and put to test the hypothesis of a unified, singular pathway, the end-product of which is lactate, the real substrate of the mitochondrial TCA cycle.

Tweak Tweak

Tweak Tweak
Author: Eve Bunting
Pages: 40
ISBN: 9780547573632
Available:
Release: 2011-05-23
Editor: Houghton Mifflin Harcourt
Language: en

Explanation of the Book:

Little Elephant and Mama Elephant are going for a walk. “Hold on to my tail,” says Mama. “If you want to ask me a question, tweak twice.” Tweak, tweak! “Mama, what is that?” Little Elephant is curious about the frog, the monkey, the songbird, the butterfly, and the crocodile—and especially about what a little elephant can do. Mama knows just how to answer, to help her cherished Little Elephant grow. Eve Bunting’s tender text and Sergio Ruzzier’s whimsical illustrations make this walk with Mama an excursion any little elephant would enjoy.

Tweak

Tweak
Author: Nic Sheff
Pages: 352
ISBN: 153443657X
Available:
Release: 2018-09-04
Editor: Atheneum Books for Young Readers
Language: en

Explanation of the Book:

The story that inspired the major motion picture Beautiful Boy featuring Steve Carell and Timothée Chalamet. This New York Times bestselling memoir of a young man’s addiction to methamphetamine tells a raw, harrowing, and ultimately hopeful tale of the road from relapse to recovery. Nic Sheff was drunk for the first time at age eleven. In the years that followed, he would regularly smoke pot, do cocaine and Ecstasy, and develop addictions to crystal meth and heroin. Even so, he felt like he would always be able to quit and put his life together whenever he needed to. It took a violent relapse one summer in California to convince him otherwise. In a voice that is raw and honest, Nic spares no detail in telling us the compelling, heartbreaking, and true story of his relapse and the road to recovery. As we watch Nic plunge into the mental and physical depths of drug addiction, he paints a picture for us of a person at odds with his past, with his family, with his substances, and with himself. It's a harrowing portrait—but not one without hope.

Patch Tweak Exploring Modular Synthesis

Patch   Tweak  Exploring Modular Synthesis
Author: Kim Bjørn
Pages: 320
ISBN: 879999951X
Available:
Release: 2018
Editor: Unknown
Language: en

Explanation of the Book:

The new book about modular synths, their makers, and masters. Patching secrets, performance tips, history, modules, and techniques. Enthusiasts call it ?The definite modular bible!?00PATCH & TWEAK provides an opportunity for new and experienced users to become true masters of their modular systems by exploring, explaining, and demystifying a range of topics relevant to anyone interested in modular synths or just synthesis itself.00Inspirational interviews with significant creators and major artists are highlights in this book. Learn about their systems, philosophies, patching secrets, performance tips, and passion for modular synthesis.0Besides a comprehensive introduction to synthesis and its history, the book covers systematic sections on concepts, purpose and creative possibilities of specific modules. Colorful diagrams, presentations of both popular and rare modules, semi-modular and software, as well as techniques for patching and how to get started, are provided.00Foreword by Suzanne Ciani.

Tweak Your Mac Terminal

Tweak Your Mac Terminal
Author: Daniel Platt
Pages: 535
ISBN: 1484261704
Available:
Release: 2020-12-05
Editor: Apress
Language: en

Explanation of the Book:

Look beyond the basics of Mac programming and development to become a Mac power user. When most people think about the Mac, they think about the amazing graphical user interface macOS is known for. However, there is a whole world to explore beneath the hood. This book approaches working directly in the terminal with fun projects and ideas to help turn you into an advanced Mac user. You'll work with Brew (HomeBrew), which gives you the ability to install applications from Linux (and Unix) that can make the terminal more useful. This is important, because a lot of applications have been stripped out of macOS or deprecated. For example, Apple's built-in PHP is usually a major release behind. You'll also customize your terminal to change everything about it, making it your own. The whole world is about personalizing. Why put up with the Apple defaults? Once you have your terminal set up and ready to rock, you'll review the basics of programming on the Mac terminal. This will allow you to get a taste of power scripting. You'll discover the power of bash, PHP, and Python. And then you'll apply those tools to web development. Tweak Your Mac Terminal takes you on a journey into a world of the terminal and its hidden applications. What You'll Learn Customize the terminal to make it perfect for your needs Develop web applications using basic coding skills in the terminal Install HomeBrew and by extension Linux and Unix applications Who This Book Is ForMac users who are already very familiar with the GUI and want to go further. This book will especially help starting IT professionals and beginning programmers.

Tweaked

Tweaked
Author: Katherine Holubitsky
Pages: 192
ISBN: 9781554697670
Available:
Release: 2008-03-01
Editor: Orca Book Publishers
Language: en

Explanation of the Book:

Sixteen-year-old Gordie Jessup is a good kid but he's living a nightmare. His eighteen-year-old brother Chase's two-year addiction to crystal meth has left their family emotionally and financially drained. And just when Gordie thinks he can no longer stand the manipulating, the lying and the stealing, things get even worse. Chase is arrested for aggravated assault, released on bail and sent home to his family. But his dealers are after him and Chase appeals to Gordie for help. Gordie, disgusted with his brother and fully aware that it's a gamble, risks everything he has in the hope of bringing his family some peace.

Tweak It

Tweak It
Author: Cali Williams Yost
Pages: 272
ISBN: 9781455517862
Available:
Release: 2013-01-08
Editor: Hachette UK
Language: en

Explanation of the Book:

As the demands of work grow more intense, personal life can get shoved to the side. But resolving the job-versus-life conflict doesn't require the kind of big, disruptive, scary transformation that so many time-management "experts" recommend. In Tweak it, Cali Williams Yost proves that a comfortable work+life fit can be achieved through making small, consistent, everyday changes -- tweaks -- that, cumulatively, will optimize job performance and well-being. This engaging, practical book, filled with case studies of people who've tweaked their way to professional success and personal satisfaction, guides readers through an easy-to-implement program that can be tailored to suit any individual's life, both on off the job.

Liver Pathophysiology

Liver Pathophysiology
Author: Pablo Muriel
Pages: 914
ISBN: 9780128043219
Available:
Release: 2017-03-02
Editor: Academic Press
Language: en

Explanation of the Book:

Liver Pathophysiology: Therapies and Antioxidants is a complete volume on morphology, physiology, biochemistry, molecular biology and treatment of liver diseases. It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants. Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies. Presents the most recent advances in hepatology, with a special focus on the role of oxidative stress in liver injury. Provides in vivo and in vitro models to study human liver pathology. Explains the beneficial effects of antioxidants on liver diseases. Contains the most recent and modern treatments of hepatic pathologies, including, but not limited to, stem cells repopulation, gene therapy and liver transplantation.

Windows 8 Tweaks

Windows 8 Tweaks
Author: Steve Sinchak
Pages: 408
ISBN: 9781118239896
Available:
Release: 2013-05-21
Editor: John Wiley & Sons
Language: en

Explanation of the Book:

Acres of Windows 8 tweaks from a Microsoft MVP and creator of Tweaks.com! From a Microsoft MVP, who is also the savvy creator of Tweaks.com, comes this ultimate collection of Windows 8 workarounds. Steve Sinchak takes you way beyond default system settings, deep under the hood of Windows 8, down to the hidden gems that let you customize your Windows 8 system like you wouldn't believe. From helping you customize the appearance to setting up home networking, sharing media, and squeezing every ounce of performance out of the OS, this book delivers. Get ready to rock and roll with Windows 8! Uncovers hidden gems to help you get the most out of Windows 8 Bypasses the default system settings to show you how to customize the login and start screens, unlock hidden settings, supercharge your network speed, get rid of features you hate, and more Provides over 400 pages of workarounds and tweaks, including many high-level ones for you hotshot techies who really love to reshape an OS and make it your own Offers expert guidance and insight from author Steve Sinchak, a Microsoft MVP and creator of Tweaks.com Start tweaking and make Windows 8 your own with Windows 8 Tweaks.

Push Turn Move

Push Turn Move
Author: Kim Bjørn
Pages: 351
ISBN: 8799999501
Available:
Release: 2017
Editor: Unknown
Language: en

Explanation of the Book:

Lesson Planning Tweaks for Teachers

Lesson Planning Tweaks for Teachers
Author: Melanie Aberson,Debbie Light
Pages: 208
ISBN: 9781472916167
Available:
Release: 2015-06-18
Editor: Bloomsbury Publishing
Language: en

Explanation of the Book:

Lesson planning is a requirement of every teacher. Whether you are planning your day-to-day lessons or a formal observation, planning is a skill that can be refined and improved to ensure your workload is manageable and your lessons exceptional. Aimed at committed and reflective teachers who want to develop their practice, this book introduces Tweaks for Teachers: small changes that make a big difference! It encourages you to review your current lesson planning practice and develop lessons that enable students to make outstanding learning gains. The book focuses on making practical, small changes that, over time, can make a real difference to the quality of learning and teaching in the classroom. Organised around real lesson snippets and full lesson plans covering every secondary subject, the book focuses on the key areas you need to plan for every lesson: assessment for learning, questioning, stretch and challenge and commitment to learning, as well as covering the importance of developing a good marking practice. Real examples of successful lessons are provided as well as a commentary of missed opportunities and practical 'tweaks' that could be made to improve students' learning and to develop outstanding teaching. This format means that the book is not only useful to those teachers wanting to develop their practice, but it is also a really useful training tool for those with responsibility for training new teachers or devolving a school's CPD provision. Lesson Planning Tweaks for Teachers takes a highly original approach to improving your lesson planning. Mel and Debbie's down to earth and accessible style will help every secondary teacher, whatever your level of experience, to make the planning process more meaningful and manageable, and one that leads to outstanding progress over time. Follow them on Twitter today for daily tips: @TeacherTweaks

Windows 7 Tweaks

Windows 7 Tweaks
Author: Steve Sinchak
Pages: 408
ISBN: 9780470633861
Available:
Release: 2010-03-02
Editor: John Wiley & Sons
Language: en

Explanation of the Book:

The definitive guide to unlocking the hidden potential of the Windows 7 OS Written by bestselling author and the creator of tweaks.com Steve Sinchak, this unique guide provides you with the ultimate collection of hidden gems that will enable you to get the most out of Windows 7. Packed with more than 400 pages of insider tips, the book delves beneath the surface to reveal little-known ways to tweak, modify, and customize Windows 7 so you can get every ounce of performance from your operating system. Regardless of your experience with tweaking your system, you'll find fascinating and fun tips and tricks for getting under the hood of Windows 7 that will allow you to optimize its appearance, speed, usability, and security. Bestselling author and creator of tweaks.com shows you how to tweak, modify, customize, and take complete control of the new Windows 7 operating system Unlocks hidden gems for optimizing the appearance, speed, usability, and security of the Windows 7 OS Shows you how to customize boot and login screens, supercharge your network and online speed, get rid of features that drive you nuts, fine tune your User Account Protection, and more So roll up your sleeves and take off your gloves so you can take total control over your Windows 7 OS!