The Gene Machine
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|Author||: Venki Ramakrishnan|
|Editor||: Basic Books|
A Nobel Prize-winning biologist tells the riveting story of his race to discover the inner workings of biology's most important molecule "Ramakrishnan's writing is so honest, lucid and engaging that I could not put this book down until I had read to the very end."--Siddhartha Mukherjee, author of The Emperor of All Maladies and The Gene Everyone has heard of DNA. But by itself, DNA is just an inert blueprint for life. It is the ribosome--an enormous molecular machine made up of a million atoms--that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases. But this is also a human story of Ramakrishnan's unlikely journey, from his first fumbling experiments in a biology lab to being the dark horse in a fierce competition with some of the world's best scientists. In the end, Gene Machine is a frank insider's account of the pursuit of high-stakes science.
|Author||: Bonnie Rochman|
|Editor||: Scientific American / Farrar, Straus and Giroux|
A sharp-eyed exploration of the promise and peril of having children in an age of genetic tests and interventions Is screening for disease in an embryo a humane form of family planning or a slippery slope toward eugenics? Should doctors tell you that your infant daughter is genetically predisposed to breast cancer? If tests revealed that your toddler has a genetic mutation whose significance isn’t clear, would you want to know? In The Gene Machine, the award-winning journalist Bonnie Rochman deftly explores these hot-button questions, guiding us through the new frontier of gene technology and how it is transforming medicine, bioethics, health care, and the factors that shape a family. Rochman tells the stories of scientists working to unlock the secrets of the human genome; genetic counselors and spiritual advisers guiding mothers and fathers through life-changing choices; and, of course, parents (including Rochman herself) grappling with revelations that are sometimes joyous, sometimes heartbreaking, but always profound. She navigates the dizzying and constantly expanding array of prenatal and postnatal tests, from carrier screening to genome sequencing, while considering how access to more tests is altering perceptions of disability and changing the conversation about what sort of life is worth living and who draws the line. Along the way, she highlights the most urgent ethical quandary: Is this technology a triumph of modern medicine or a Pandora’s box of possibilities? Propelled by human narratives and meticulously reported, The Gene Machine is both a scientific road map and a meditation on our power to shape the future. It is a book that gets to the very core of what it means to be human.
|Author||: Charles Graeber|
|Editor||: Harper Collins|
For decades, scientists have puzzled over one of medicine's most confounding mysteries: Why doesn't our immune system recognize and fight cancer the way it does other diseases, like the common cold? As it turns out, the answer to that question can be traced to a series of tricks that cancer has developed to turn off normal immune responses-tricks that scientists have only recently discovered and learned to defeat. The result is what many are calling cancer's "penicillin moment," a revolutionary discovery in our understanding of cancer and how to beat it. Journalist Charles Graeber expertly traces the fascinating history of immuno-oncology and guides readers through the revolutionary scientific research bringing cancer treatment into the 21st century. As advances in our understanding of cancer and the human immune system continue to fuel a therapeutic arms race among biotech and pharmaceutical companies around the world, the next step - harnessing the wealth of new information into modern and more effective patient therapies - is already well underway. Groundbreaking, riveting, and expertly told, The Breakthrough is the story of the game-changing scientific discoveries that unleash our natural ability to recognize and defeat cancer, as told through the experiences of the patients, physicians, and cancer immunotherapy researchers who are on the front lines. This is the incredible true story of the race to find a cure, a dispatch from the life-changing world of modern oncological science, and a brave new chapter in medical history.
|Author||: Siddhartha Mukherjee|
|Editor||: Simon and Schuster|
The #1 NEW YORK TIMES Bestseller The basis for the PBS Ken Burns Documentary The Gene: An Intimate History From the Pulitzer Prize–winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle). "Sid Mukherjee has the uncanny ability to bring together science, history, and the future in a way that is understandable and riveting, guiding us through both time and the mystery of life itself." –Ken Burns “Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices. “Mukherjee expresses abstract intellectual ideas through emotional stories…[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” (The Washington Post). Throughout, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome. “A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. “The Gene is a book we all should read” (USA TODAY).
|Author||: Richard Dawkins,Charles Simonyi Professor of the Public Understanding of Science Richard Dawkins,David Dawkins,RICHARD AUTOR DAWKINS|
|Editor||: Oxford University Press, USA|
An ethologist shows man to be a gene machine whose world is one of savage competition and deceit
|Author||: Gene Mustain,Jerry Capeci|
"The inside story of a single Brooklyn gang that killed more Americans than the Iraqi army."—Mike McAlary, columnist, New York Post They were the DeMeo gang—the most deadly hit men in organized crime. Their Mafia higher-ups came to know, use, and ultimately fear them as the Murder Machine. They killed for profit and for pleasure, following cold-blooded plans and wild whims, from the mean streets of New York to the Florida Gold Coast, and from coast to coast. Now complete with personal revelations of one of the key players, this is the savage story that leaves no corpse unturned in its terrifying telling. INCLUDES PHOTOGRAPHS
|Author||: Lee Tang|
|Editor||: LMT Press|
The promise and peril of having children in an age of genetic tests and interventions. This is a summary of “The Gene Machine: How Genetic Technologies Are Changing the Way We Have Kids — and the Kids We Have,” by Bonnie Rochman. This book covers a variety of topics from breast cancer to Tay-Sachs, several pre-natal genetic mapping technologies, genome sequencing, rare disease diagnosis, silencing of a gene, and repairing gene defects using gene editing tools (CRISPR). It covers the question of testing for Down syndrome and abortion, and the emotionally and morally fraught decisions individuals are forced to make when confronting the information these tests reveal. Over the past few years, genetic testing has expanded into a full array of testing available prenatally, postnatally, and even pre-conception. A more targeted analysis has allowed women to weed out unhealthy embryos before attempting pregnancy. Genome sequencing gives the child’s blueprint, including a predisposition to diseases such as Down syndrome, early-onset Alzheimer’s, or breast cancer. Having access to so much information can be empowering, enlightening, confusing, and frightening. It can enable parents to prepare for a child with special needs. Or it could allow them to end the pregnancy. This is a must read for those planning on having kids, or for those who simply want to learn about genetic technologies. This guide includes: * Book Summary—helps you understand the key concepts. * Online Videos—cover the concepts in more depth. Value-added from this guide: * Save time * Understand key concepts * Expand your knowledge
|Author||: Susan Blackmore|
|Editor||: OUP Oxford|
Humans are extraordinary creatures, with the unique ability among animals to imitate and so copy from one another ideas, habits, skills, behaviours, inventions, songs, and stories. These are all memes, a term first coined by Richard Dawkins in 1976 in his book The Selfish Gene. Memes, like genes, are replicators, and this enthralling book is an investigation of whether this link between genes and memes can lead to important discoveries about the nature of the inner self. Confronting the deepest questions about our inner selves, with all our emotions, memories, beliefs, and decisions, Susan Blackmore makes a compelling case for the theory that the inner self is merely an illusion created by the memes for the sake of replication.
|Author||: Matthew Cobb|
|Editor||: Basic Books|
Everyone has heard of the story of DNA as the story of Watson and Crick and Rosalind Franklin, but knowing the structure of DNA was only a part of a greater struggle to understand life’s secrets. Life’s Greatest Secret is the story of the discovery and cracking of the genetic code, the thing that ultimately enables a spiraling molecule to give rise to the life that exists all around us. This great scientific breakthrough has had farreaching consequences for how we understand ourselves and our place in the natural world, and for how we might take control of our (and life’s) future. Life’s Greatest Secret mixes remarkable insights, theoretical dead-ends, and ingenious experiments with the swift pace of a thriller. From New York to Paris, Cambridge, Massachusetts, to Cambridge, England, and London to Moscow, the greatest discovery of twentieth-century biology was truly a global feat. Biologist and historian of science Matthew Cobb gives the full and rich account of the cooperation and competition between the eccentric characters—mathematicians, physicists, information theorists, and biologists—who contributed to this revolutionary new science. And, while every new discovery was a leap forward for science, Cobb shows how every new answer inevitably led to new questions that were at least as difficult to answer: just ask anyone who had hoped that the successful completion of the Human Genome Project was going to truly yield the book of life, or that a better understanding of epigenetics or “junk DNA” was going to be the final piece of the puzzle. But the setbacks and unexpected discoveries are what make the science exciting, and it is Matthew Cobb’s telling that makes them worth reading. This is a riveting story of humans exploring what it is that makes us human and how the world works, and it is essential reading for anyone who’d like to explore those questions for themselves.
|Author||: Quan Zou,Arun Kumar Sangaiah,Dariusz Mrozek|
|Editor||: Frontiers Media SA|
|Author||: Thomas A. Easton,Algis Budrys,Mike Resnick|
|Editor||: Wildside Press LLC|
Genetic engineering is a technological infant, barely taking it's first baby steps. This collection of stories explores what happens when a boy starts doing strange things with Moms' violets; sports cars run away and go to sea, and Mother Goose comes to life with pumpkin houses and giant bean stalks.
|Author||: Kevin Davies|
|Editor||: Simon and Schuster|
In 2000, President Bill Clinton signaled the completion of the Human Genome Project at a cost in excess of $2 billion. A decade later, the price for any of us to order our own personal genome sequence--a comprehensive map of the 3 billion letters in our DNA--is rapidly and inevitably dropping to just $1,000. Dozens of men and women--scientists, entrepreneurs, celebrities, and patients--have already been sequenced, pioneers in a bold new era of personalized genomic medicine. The $1,000 genome has long been considered the tipping point that would open the floodgates to this revolution. Do you have gene variants associated with Alzheimer's or diabetes, heart disease or cancer? Which drugs should you consider taking for various diseases, and at what dosage? In the years to come, doctors will likely be able to tackle all of these questions--and many more--by using a computer in their offices to call up your unique genome sequence, which will become as much a part of your medical record as your blood pressure.
|Author||: Steven J. Heine|
|Editor||: W. W. Norton|
"Do you fear what might be lurking in your DNA? Well, now you can find out, and you most likely will. Scientists expect one billion people to have their genomes sequenced by 2025, and as the price drops it may even become a standard medical procedure. Yet cultural psychologist Steven J. Heine argues that the first thing we'll do upon receiving our DNA test results is to misinterpret them completely. We've become accustomed to breathless media coverage about newly discovered "cancer" or "IQ" or "infidelity" genes, each one promising a deeper understanding of what makes us tick. But as Heine shows, most of these claims are oversimplified and overhyped misinterpretations of how our DNA really works. With few exceptions, it is a complex combination of experience, environment, and genetics that determines who we are, how we behave, and what diseases will afflict us in the future. So why do we continue to buy into the belief that our genes control our destiny? Heine argues that we are psychologically ill equipped to deal with DNA results, repeatedly falling into predictable biases--switch-thinking, essentialism, fatalism, negativity dominance, and more--that mold our thinking about the information we receive. Heine shares his research--and his own genome-sequencing results--not only to set the record straight regarding what your genes actually reveal about your health, intelligence, ethnic identity, and family, but also to help you counteract these insidious cognitive traps. His fresh, surprising conclusions about the promise, and limits, of genetic engineering and DNA testing upend conventional thinking and reveal a simple, profound truth: your genes create life--but they do not control it."--Jacket.
|Author||: Altuna Akalin|
|Editor||: Chapman & Hall/CRC Computational Biology Series|
Computational Genomics with R provides a starting point for beginners in genomic data analysis and also guides more advanced practitioners to sophisticated data analysis techniques in genomics. The book covers topics from R programming, to machine learning and statistics, to the latest genomic data analysis techniques. The text provides accessible information and explanations, always with the genomics context in the background. This also contains practical and well-documented examples in R so readers can analyze their data by simply reusing the code presented. As the field of computational genomics is interdisciplinary, it requires different starting points for people with different backgrounds. For example, a biologist might skip sections on basic genome biology and start with R programming, whereas a computer scientist might want to start with genome biology. After reading: You will have the basics of R and be able to dive right into specialized uses of R for computational genomics such as using Bioconductor packages. You will be familiar with statistics, supervised and unsupervised learning techniques that are important in data modeling, and exploratory analysis of high-dimensional data. You will understand genomic intervals and operations on them that are used for tasks such as aligned read counting and genomic feature annotation. You will know the basics of processing and quality checking high-throughput sequencing data. You will be able to do sequence analysis, such as calculating GC content for parts of a genome or finding transcription factor binding sites. You will know about visualization techniques used in genomics, such as heatmaps, meta-gene plots, and genomic track visualization. You will be familiar with analysis of different high-throughput sequencing data sets, such as RNA-seq, ChIP-seq, and BS-seq. You will know basic techniques for integrating and interpreting multi-omics datasets. Altuna Akalin is a group leader and head of the Bioinformatics and Omics Data Science Platform at the Berlin Institute of Medical Systems Biology, Max Delbrück Center, Berlin. He has been developing computational methods for analyzing and integrating large-scale genomics data sets since 2002. He has published an extensive body of work in this area. The framework for this book grew out of the yearly computational genomics courses he has been organizing and teaching since 2015.
|Author||: Michael Kormann|
|Editor||: BoD – Books on Demand|
Site-specific endonucleases create double-strand breaks within the genome and can be targeted to literally any genetic mutation. Together with a repair template, a correction of the defective locus becomes possible. This book offers insight into the modern tools of genome editing, their hurdles and their huge potential. A new era of in vivo genetic engineering has begun.
|Author||: Xiaoyi Raymond Gao|
|Editor||: Academic Press|
Genetics and Genomics of Eye Disease: Advancing to Precision Medicine thoroughly examines the latest genomics methods for studying eye disease, including complex eye disorders associated with multiple genes. GWAS, WES, WGS, RNA-sequencing, and transcriptome analysis as employed in ocular genomics are discussed in-depth, as are genomics findings tied to early-onset glaucoma, strabismus, age-related macular degeneration, adult-onset glaucoma, diabetic retinopathy, keratoconus, and leber congenital amaurosis, among other diseases. Research and clinical specialists offer guidance on conducting preventative screenings and counseling patients, as well as the promise of machine learning, computational statistics and artificial intelligence in advancing ocular genomics research. Offers thorough guidance on conducting genetic and genomic studies of eye disease Examines the genetic basis of a wide range of complex eye diseases and single-gene and Mendelian disorders Discusses the application of genetic testing and genetic risk prediction in eye disease diagnosis and patient counseling